Despite the high safety profile demonstrated in clinical trials, the immunogenicity of adeno-associated virus (AAV)-mediated gene therapy remains a major hurdle.Specifically, T-cell-mediated immune responses to AAV vectors are related to loss of efficacy and potential liver toxicities.As post-translational modifications in T cell epitopes have the
It is often the case that data used for the systems reliability assessment comes from more than one information source.Whether they are power plants at different geographical locations, gas transmission pipelines operating in different environment or power transmission networks deployed within various areas.Therefore, different operating conditions
Context: Despite the advances in orthodontic material and treatment mechanics, the placement of fixed appliances increases the risk of enamel demineralization.The development of fluoride release adhesives has attracted considerable interests because the combined use of antimicrobials and fluoride enhances the cariostatic effect.Aim: To compare the
Attentional control refers to the regulatory processes that ensure that our actions are in accordance with our goals.Dual-system accounts view temperament as consisting of both individual variation in emotionality (e.g.trait anxiety) and variation in regulatory attentional mechanisms that act to modulate emotionality.Increasing evidence links TV Co